Saturday, 30 June 2012

sumatriptan injection



Generic Name: sumatriptan (injection) (soo ma TRIP tan)

Brand Names: Alsuma, Imitrex, Imitrex Statdose, Imitrex Statdose Refill, Sumavel DosePro


What is sumatriptan injection?

Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.


Sumatriptan is used to treat migraine headaches and cluster headaches. Sumatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.


Sumatriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medication only if your condition has been confirmed by a doctor as migraine headaches.

Sumatriptan may also be used for purposes not listed in this medication guide.


What is the most important information I should know about sumatriptan injection?


You should not use this medication if you are allergic to sumatriptan, if you have any history of heart disease, or if you have coronary heart disease, angina, blood circulation problems, lack of blood supply to the heart, uncontrolled high blood pressure, severe liver disease, ischemic bowel disease, a history of a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including sumatriptan tablets or nasal spray, almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), rizatriptan (Maxalt), naratriptan (Amerge), zolmitriptan (Zomig), or ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine). Do not use sumatriptan if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

Before using sumatriptan, tell your doctor if you have liver or kidney disease, seizures, high blood pressure, a heart rhythm disorder, or coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).


Also tell your doctor if you are taking an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).


Sumatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.


After using a sumatriptan injection, you must wait one (1) hour before using a second injection. Do not use more than two injections in 24 hours.


What should I discuss with my health care provider before using sumatriptan injection?


You should not use this medication if you are allergic to sumatriptan, or if you have:

  • coronary heart disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;




  • a history of heart disease, heart attack, or stroke, including "mini-stroke";




  • severe or uncontrolled high blood pressure;



  • severe liver disease;


  • ischemic bowel disease; or




  • a headache that seems different from your usual migraine headaches.




Do not use sumatriptan if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

To make sure you can safely use sumatriptan, tell your doctor if you have any of these other conditions:


  • liver disease;

  • kidney disease;


  • epilepsy or other seizure disorder;




  • high blood pressure, a heart rhythm disorder; or




  • coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).




FDA pregnancy category C. It is not known whether sumatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Your name may need to be listed on a sumatriptan pregnancy registry when you start using this medication.


Sumatriptan can pass into breast milk and may harm a nursing baby. Do not breast-feed within 12 hours after using a sumatriptan injection. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. This medicine should not be given to anyone under 18 or over 65 years of age.

How should I use sumatriptan injection?


Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Overuse of migraine headache medicine can actually make your headaches worse.


Sumatriptan is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.


This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.


Use sumatriptan as soon as you notice headache symptoms, or after an attack has already begun.


Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.


Sumatriptan injection comes in a vial (bottle), in a prefilled cartridge to be loaded into an auto-injector syringe (Imitrex Statdose), or in a needle-free injector device (Sumavel DosePro). Each vial, cartridge, or needle-free device is for one use only.


After using an injection: If your headache does not completely go away after the injection, call your doctor before using a second sumatriptan injection. If your headache goes away and then comes back, you may use a second injection if it has been at least one hour since your first injection. Do not use more than two (2) injections in 24 hours. If your symptoms do not improve, contact your doctor before using any more injections.


Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed.

What happens if I miss a dose?


Since sumatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using sumatriptan.


After using a sumatriptan injection, you must wait one (1) hour before using a second injection. Do not use more than two (2) injections in 24 hours.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include tremors or shaking, skin redness, breathing problems, blue-colored lips or fingernails, vision problems, watery eyes or mouth, weakness, lack of coordination, or seizure (convulsions).


What should I avoid while using sumatriptan injection?


Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including:

  • sumatriptan tablets or nasal spray, almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig); or




  • ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).




Sumatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Sumatriptan injection side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sumatriptan and call your doctor if you have a serious side effect such as:

  • feeling of pain or tightness in your jaw, neck, or throat;




  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;




  • sudden numbness or weakness, especially on one side of the body;




  • sudden severe headache, confusion, problems with vision, speech, or balance;




  • sudden and severe stomach pain and bloody diarrhea;




  • seizure (convulsions);




  • numbness or tingling and a pale or blue-colored appearance in your fingers or toes; or




  • (if you are also taking an antidepressant) -- agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.



Less serious side effects may include:



  • mild headache (not a migraine);




  • pressure or heavy feeling in any part of your body;




  • discomfort in your nose or throat;




  • dizziness, spinning sensation;




  • muscle pain, neck pain or stiffness;




  • warmth, redness, or mild tingling under your skin; or




  • pain, redness, bleeding, swelling, or bruising where you injected the medicine.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Sumatriptan Dosing Information


Usual Adult Dose for Cluster Headache:

Initial dosage when symptoms of headache appear:

Subcutaneously: 4 to 6 mg; may repeat if needed at least 1 hour after initial dose; maximum: 12 mg/day.

ORAL: Initial single dose: 25 mg given with fluids as soon as possible after the onset of a migraine; range: 25 to 100 mg/dose; maximum single dose: 100 mg; may repeat after 2 hours; maximum: 200 mg/day taken. The maximum single oral dose recommended is 100 mg. Do not split tablets.

NASAL SPRAY: Initial single dose: 5 mg, 10 mg, or 20 mg administered in one nostril, given as soon as possible after the onset of migraine; 10 mg dose may be administered as 5 mg in each nostril; may repeat after 2 hours; maximum: 40 mg/day.

Usual Adult Dose for Migraine:

Initial dosage when symptoms of headache appear:

Subcutaneously: 4 to 6 mg; may repeat if needed at least 1 hour after initial dose; maximum: 12 mg/day.

ORAL: Initial single dose: 25 mg given with fluids as soon as possible after the onset of a migraine; range: 25 to 100 mg/dose; maximum single dose: 100 mg; may repeat after 2 hours; maximum: 200 mg/day taken. The maximum single oral dose recommended is 100 mg. Do not split tablets.

NASAL SPRAY: Initial single dose: 5 mg, 10 mg, or 20 mg administered in one nostril, given as soon as possible after the onset of migraine; 10 mg dose may be administered as 5 mg in each nostril; may repeat after 2 hours; maximum: 40 mg/day.

Usual Pediatric Dose for Migraine:

Use in children and adolescents less than 18 years of age not recommended by manufacturer. Results of clinical studies are mixed with regards to efficacy, particularly with oral and injectable sumatriptan.

Intranasal:
Children 5 to 12 years: 5 mg, 10 mg, or 20 mg administered in one nostril as a single dose. A double-blind, placebo controlled study of 129 patients (8 to 17 years) used a weight-based dosing regimen: 20 to 39 kg: 10 mg; 40 kg or more: 20 mg. A small retrospective review of 10 children (5 to 12 years; mean: 9.9 years), used intranasal doses of 5 mg (n=2) or 20 mg (n=8).
Adolescents 12 years or older: 5 mg, 10 mg, or 20 mg administered in one nostril as a single dose.

Subcutaneously: Children and Adolescents 6 to 18 years: 3 to 6 mg single dose. An open labeled prospective trial of 17 children 6 to 16 years with juvenile migraine used subcutaneous doses of 6 mg in 15 children (30 to 70 kg), and 3 mg/dose in two children (22 kg and 30 kg). Another open-label prospective trial in 50 consecutive children (ages 6 to 18 years) with severe migraine used subcutaneous doses of 0.06 mg/kg/dose. Relief was reported as good/excellent in 84% of the patients; 16% reported fair to poor relief; additional studies are needed.


What other drugs will affect sumatriptan injection?


Tell your doctor about all other medicines you use, especially:



  • an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).



This list is not complete and other drugs may interact with sumatriptan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More sumatriptan resources


  • Sumatriptan Side Effects (in more detail)
  • Sumatriptan Use in Pregnancy & Breastfeeding
  • Drug Images
  • Sumatriptan Drug Interactions
  • Sumatriptan Support Group
  • 104 Reviews for Sumatriptan - Add your own review/rating


Compare sumatriptan with other medications


  • Cluster Headaches
  • Cyclic Vomiting Syndrome
  • Migraine
  • New Daily Persistent Headache


Where can I get more information?


  • Your pharmacist can provide more information about sumatriptan.

See also: sumatriptan side effects (in more detail)


Isib 60 XL




Isib 60 XL may be available in the countries listed below.


Ingredient matches for Isib 60 XL



Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isib 60 XL in the following countries:


  • United Kingdom

International Drug Name Search

Tuesday, 26 June 2012

Vecuronium


Pronunciation: ve-KYOO-roe-ni-um
Generic Name: Vecuronium
Brand Name: Generic only. No brands available.

This medication should only be given by doctors who are experienced in the use of this medication. Proper life support equipment and personnel should be available in case of an emergency.





Vecuronium is used for:

Relaxing muscles during surgery and mechanical breathing.


Vecuronium is a neuromuscular blocking agent. It works by blocking nerve transmissions in muscle nerves, which results in muscle relaxation and paralysis.


Do NOT use Vecuronium if:


  • you are allergic to any ingredient in Vecuronium

  • you have diarrhea due to poisoning or pseudomembranous colitis

  • you are taking quinine or quinidine

Contact your doctor or health care provider right away if any of these apply to you.



Before using Vecuronium:


Some medical conditions may interact with Vecuronium. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of asthma, an enlarged prostate, trouble urinating, circulation problems, electrolyte problems, a blockage of your bladder, irregular heartbeat or other heart problems, liver or kidney problems, adrenal gland problems, underactive thyroid, lung problems (chronic obstructive pulmonary disease [COPD], cor pulmonale), myasthenia gravis or Eaton-Lambert syndrome, mood or mental problems, suicidal thoughts or behaviors, serious head injury, increased pressure in the brain, unusual growths in the brain, seizures, or severe inflammatory bowel disease

  • if you have a history of substance abuse or you are having stomach or intestinal surgery

Some MEDICINES MAY INTERACT with Vecuronium. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Aminoglycosides (eg, gentamicin), clindamycin, cyclosporine, inhalation anesthetics (eg, enflurane), lincomycin, magnesium salts, polypeptide antibiotics (eg, bacitracin), quinidine, quinine, trimethaphan, or verapamil because the side effects of Vecuronium may be increased

  • Carbamazepine, hydantoins, other nondepolarizing neuromuscular blockers (eg, pancuronium), tetracyclines (eg, doxycycline), theophyllines, or thiopurines because the effectiveness of Vecuronium may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vecuronium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Vecuronium:


Use Vecuronium as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Vecuronium is usually administered as an injection at your doctor's office, hospital, or clinic.

  • If Vecuronium contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.

  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use.

  • If you miss a dose of Vecuronium, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Vecuronium.



Important safety information:


  • Vecuronium may cause a change in circulation time for patients with heart problems or increased age.

  • Patients with severe obesity or neuromuscular disease may have airway and/or breathing problems requiring special care before, during, and after the use of neuromuscular blocking agents such as vecuronium.

  • Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Vecuronium. Symptoms may include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; fast or irregular heartbeat; and sweating. Contact your doctor at once if any of these symptoms occur.

  • Use Vecuronium with caution in the ELDERLY because they may be more sensitive to its effects.

  • Vecuronium contains benzyl alcohol, a preservative. Do not use Vecuronium in NEWBORNS because serious and sometimes fatal nervous system problems and other side effects may occur.

  • Use Vecuronium with extreme caution in CHILDREN younger than 7 weeks of age. Safety and effectiveness in this age group have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Vecuronium during pregnancy. It is unknown if Vecuronium is excreted in breast milk. If you are or will be breast-feeding while you are using Vecuronium, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Vecuronium:


All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:



Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dizziness; fever; prolonged muscle weakness; unusually fast or slow heart rate.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Vecuronium side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing; muscle weakness.


Proper storage of Vecuronium:

Vecuronium is usually handled and stored by a health care provider. If you are using Vecuronium at home, store Vecuronium as directed by your pharmacist or health care provider.


General information:


  • If you have any questions about Vecuronium, please talk with your doctor, pharmacist, or other health care provider.

  • Vecuronium is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Vecuronium. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Vecuronium resources


  • Vecuronium Side Effects (in more detail)
  • Vecuronium Use in Pregnancy & Breastfeeding
  • Vecuronium Drug Interactions
  • Vecuronium Support Group
  • 0 Reviews for Vecuronium - Add your own review/rating


  • Vecuronium Prescribing Information (FDA)

  • vecuronium Concise Consumer Information (Cerner Multum)

  • Norcuron Monograph (AHFS DI)

  • Vecuronium Bromide Professional Patient Advice (Wolters Kluwer)



Compare Vecuronium with other medications


  • Anesthesia

Imonogas




Imonogas may be available in the countries listed below.


Ingredient matches for Imonogas



Simeticone

Simeticone is reported as an ingredient of Imonogas in the following countries:


  • Belgium

  • France

  • Luxembourg

International Drug Name Search

Monday, 25 June 2012

Neo-Fradin


Generic Name: neomycin (Oral route)

nee-oh-MYE-sin

Oral route(Tablet;Solution)

Systemic absorption occurs following oral administration and toxic reactions may occur. Therapy has been associated with potential neurotoxicity, ototoxicity, and nephrotoxicity. Patients with impaired renal function, advanced age, dehydration, and those who receive high dosage or prolonged therapy are at an increased risk of toxicity. Monitor renal and auditory function during therapy. Aminoglycoside-induced ototoxicity is usually irreversible. Neuromuscular blockade and respiratory paralysis have also been reported following administration. Concurrent use of other potentially neurotoxic or nephrotoxic agents, or potent diuretics should be avoided .



Commonly used brand name(s)

In the U.S.


  • Neo-Fradin

Available Dosage Forms:


  • Tablet

  • Solution

Therapeutic Class: Antibiotic


Chemical Class: Aminoglycoside


Uses For Neo-Fradin


Oral neomycin is used to help lessen the symptoms of hepatic coma, a complication of liver disease. In addition, it may be used with another medicine before any surgery affecting the bowels to help prevent infection during surgery.


Neomycin is available only with your doctor's prescription.


Before Using Neo-Fradin


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Damage to hearing, sense of balance, and kidneys is more likely to occur in premature infants and neonates, who are more sensitive than adults to the effects of neomycin.


Geriatric


Serious side effects, such as damage to hearing, sense of balance, and kidneys may occur in elderly patients, who are usually more sensitive than younger adults to the effects of neomycin.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Alcuronium

  • Atracurium

  • Cidofovir

  • Cisatracurium

  • Colistimethate Sodium

  • Decamethonium

  • Doxacurium

  • Ethacrynic Acid

  • Fazadinium

  • Furosemide

  • Gallamine

  • Hexafluorenium

  • Metocurine

  • Mivacurium

  • Pancuronium

  • Pipecuronium

  • Rapacuronium

  • Rocuronium

  • Sorafenib

  • Tacrolimus

  • Tubocurarine

  • Vecuronium

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Bumetanide

  • Digoxin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Blockage of the bowel

  • Eighth-cranial-nerve disease (loss of hearing and/or balance)—Oral neomycin may increase the chance of hearing loss and/or balance problems

  • Kidney disease—Patients with kidney disease may have an increased chance of side effects

  • Myasthenia gravis or

  • Parkinson's disease—Patients with myasthenia gravis or Parkinson's disease may have an increased chance of developing muscular weakness

  • Ulcers of the bowel—Patients with ulcers of the bowel may have an increased chance of side effects since more neomycin may be absorbed by the body

Proper Use of Neo-Fradin


This medicine may be taken on a full or empty stomach.


For patients taking the oral liquid form of neomycin:


  • Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Keep taking this medicine for the full time of treatment. Do not miss any doses.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage forms (solution, tablets):
    • For patients in a coma from liver disease:
      • Adults and teenagers—1 to 3 grams every six hours for five or six days.

      • Children—Dose is based on body size (not weight) and must be determined by your doctor. That dose is given every six hours for five or six days.


    • For cleaning the bowel before surgery:
      • Adults and teenagers—1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery.

      • Children—Dose is based on body weight. The usual dose is 14.7 milligrams (mg) per kilogram (kg) (6.7 mg per pound) of body weight every four hours for three days.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Neo-Fradin Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Rare
  • Any loss of hearing

  • clumsiness

  • diarrhea

  • difficulty in breathing

  • dizziness

  • drowsiness

  • greatly decreased frequency of urination or amount of urine

  • increased amount of gas

  • increased thirst

  • light-colored, frothy, fatty-appearing stools

  • ringing or buzzing or a feeling of fullness in the ears

  • skin rash

  • unsteadiness

  • weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Irritation or soreness of the mouth or rectal area

  • nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Neo-Fradin side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Neo-Fradin resources


  • Neo-Fradin Side Effects (in more detail)
  • Neo-Fradin Use in Pregnancy & Breastfeeding
  • Neo-Fradin Drug Interactions
  • Neo-Fradin Support Group
  • 0 Reviews for Neo-Fradin - Add your own review/rating


  • Neo-Fradin Solution MedFacts Consumer Leaflet (Wolters Kluwer)

  • Neo-Fradin Prescribing Information (FDA)

  • Neo-Fradin Concise Consumer Information (Cerner Multum)

  • Neomycin MedFacts Consumer Leaflet (Wolters Kluwer)

  • Neomycin Sulfate Monograph (AHFS DI)



Compare Neo-Fradin with other medications


  • Bowel Preparation
  • Diarrhea
  • Hepatic Coma
  • Hepatic Encephalopathy

Sunday, 24 June 2012

Panlor DC


Pronunciation: a-seet-a-MIN-oh-fen/KAF-een/dye-hye-droe-KOE-deen
Generic Name: Acetaminophen/Caffeine/Dihydrocodeine
Brand Name: Examples include Trezix and Panlor SS

Panlor DC contains acetaminophen. Severe and sometimes fatal liver problems, including the need for liver transplant, have been reported with the use of acetaminophen. Most cases of these liver problems occurred in patients taking excessive doses of acetaminophen (more than 4,000 mg per day). Also, patients who developed these liver problems were often using more than 1 medicine that contained acetaminophen. Discuss any questions or concerns with your doctor.





Panlor DC is used for:

Relieving moderate to moderately severe pain. It may also be used for other conditions as determined by your doctor.


Panlor DC is an analgesic combination. It works in certain areas of the brain and nervous system to decrease pain.


Do NOT use Panlor DC if:


  • you are allergic to any ingredient in Panlor DC or any other codeine- or morphine-related medicine (eg, oxycodone)

  • you have severe diarrhea due to taking an antibiotic, severe bowel problems (eg, paralytic ileus), severe asthma, or if you are having an asthma attack

  • you are taking naltrexone, quinidine, or sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Panlor DC:


Some medical conditions may interact with Panlor DC. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you drink more than 3 alcohol-containing drinks per day or have a history of alcohol or substance abuse, or suicidal thoughts or behavior

  • if you have recently had a head injury or if you have a history of brain injury or tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures

  • if you have a history of asthma or other lung or breathing problems, stomach or bowel problems, gallbladder problems (eg, gallstones), or pancreas problems (eg, pancreatitis)

  • if you have Addison disease, heart problems, liver problems (eg, hepatitis), an underactive thyroid, prostate problems, kidney problems, urinary problems, or if you have had recent abdominal surgery

Some MEDICINES MAY INTERACT with Panlor DC. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Naltrexone because the effectiveness of Panlor DC will be decreased and withdrawal symptoms may occur if you are physically dependent on opioids. You must not take naltrexone until you have stopped taking Panlor DC for 7 to 10 days and after a naloxone challenge test is negative.

  • Quinidine because the effectiveness of Panlor DC may be decreased

  • Cimetidine, ethanol, HIV protease inhibitors (eg, ritonavir), isoniazid, medicine for mental or mood disorders (eg, olanzapine, haloperidol), medicine for anxiety (eg, diazepam), other narcotic pain medicine (eg, oxycodone), monoamine oxidase (MAO) inhibitors (eg, phenelzine), or sodium oxybate (GHB) because side effects such as excessive drowsiness, disorientation, trouble breathing, or seizures may occur

  • Anticoagulants (eg, warfarin) because side effects such as bleeding may be increased by Panlor DC

This may not be a complete list of all interactions that may occur. Ask your health care provider if Panlor DC may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Panlor DC:


Use Panlor DC as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Panlor DC may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation. However, this may decrease its effectiveness.

  • If you miss a dose of Panlor DC and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Panlor DC.



Important safety information:


  • Panlor DC may cause drowsiness, dizziness, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Panlor DC. Using Panlor DC alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Panlor DC. Panlor DC will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

  • Panlor DC may cause liver damage. If you drink 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Panlor DC or other pain relievers/fever reducers. Alcohol use combined with Panlor DC may increase your risk for liver damage.

  • When using for an extended period, Panlor DC may not work as well and may require different dosing. Talk with your doctor if Panlor DC stops working well.

  • Panlor DC contains acetaminophen. Do not take additional acetaminophen for pain or fever without checking with your doctor or pharmacist. Ask your doctor or pharmacist if you have any questions about which medicines contain acetaminophen.

  • Panlor DC may cause constipation. To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while taking Panlor DC, talk with your doctor or pharmacist. A stool softener or fiber laxative may be required.

  • If nausea occurs, consult your doctor or pharmacist about alternatives for decreasing nausea (eg, taking antihistamines, lying down for 1 to 2 hours with minimal head movement).

  • To minimize dizziness or lightheadedness, get up slowly when rising from a seated or lying position.

  • Caution is advised when using Panlor DC in the ELDERLY because they may be more sensitive to the effects of the medicine, especially drowsiness and trouble breathing.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Panlor DC, discuss with your doctor the benefits and risks of using Panlor DC during pregnancy. Panlor DC is excreted in breast milk. Do not breast-feed while taking Panlor DC.

When used for long periods of time or at high doses, Panlor DC may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Panlor DC stops working well. Do not take more than prescribed.


Panlor DC may be habit-forming and lead to DEPENDENCE if used in high doses or for a long period of time. If you are on long-term or high dosage therapy, you may have WITHDRAWAL symptoms (eg, convulsions, tremor, stomach and muscle cramps, vomiting, sweating) if you suddenly stop taking Panlor DC. Do not stop therapy abruptly or change dosage without asking your pharmacist or doctor. Discuss overuse with your doctor or pharmacist.



Possible side effects of Panlor DC:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Blurred vision; constipation; dizziness; drowsiness; exaggerated sense of well-being; feeling unwell or unhappy; flushing; lightheadedness; mental/mood changes; nausea; nervousness or anxiety; stomach pain; vision changes; vomiting.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; dark urine; difficulty breathing; slow/irregular breathing; slow/irregular heartbeat; stomach pain; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Panlor DC side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold, clammy skin; extreme drowsiness; fatigue; loss of consciousness; persistent nausea/vomiting; slow heartbeat; slow, shallow, or abnormal breathing; stomach pain; unusual sweating; weakness; yellowing of the skin or eyes.


Proper storage of Panlor DC:

Store Panlor DC at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Panlor DC out of the reach of children and away from pets.


General information:


  • If you have any questions about Panlor DC, please talk with your doctor, pharmacist, or other health care provider.

  • Panlor DC is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Panlor DC. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Panlor DC resources


  • Panlor DC Side Effects (in more detail)
  • Panlor DC Use in Pregnancy & Breastfeeding
  • Drug Images
  • Panlor DC Drug Interactions
  • Panlor DC Support Group
  • 1 Review for Panlor DC - Add your own review/rating


  • Panlor DC Concise Consumer Information (Cerner Multum)

  • Trezix Prescribing Information (FDA)



Compare Panlor DC with other medications


  • Pain

Saturday, 23 June 2012

Magaldrate Suspension


Pronunciation: MAG-al-drate
Generic Name: Magaldrate
Brand Name: Examples include Ri-Mag and Ron-Acid


Magaldrate Suspension is used for:

Treating acid indigestion, heartburn, and sour stomach. It may also be used for other conditions as determined by your doctor.


Magaldrate Suspension is an antacid. It works by neutralizing stomach acid and increasing the pH of the stomach.


Do NOT use Magaldrate Suspension if:


  • you are allergic to any ingredient in Magaldrate Suspension

  • you have a history of kidney problems

  • you are taking citrate salts (found in some calcium supplements, antacids, and laxatives)

Contact your doctor or health care provider right away if any of these apply to you.



Before using Magaldrate Suspension:


Some medical conditions may interact with Magaldrate Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have appendicitis, stomach pain, nausea, vomiting, diarrhea, blockage of the bowel, rectal bleeding of unknown cause, kidney problems, or you have had bowel surgery

Some MEDICINES MAY INTERACT with Magaldrate Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Oral blood thinners (eg, warfarin), citrate salts (found in some calcium supplements, antacids, and laxatives), or quinidine because their actions and side effects may be increased by Magaldrate Suspension

  • Bisphosphonates (eg, alendronic acid), cation exchange resins (eg, sodium polystyrene sulfonate), cephalosporins (eg, cefaclor), imidazoles (eg, fluconazole), mycophenolate, penicillamine, quinolones (eg, ciprofloxacin), tetracyclines (eg, doxycycline), or thyroid hormones because their effectiveness may be decreased by Magaldrate Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Magaldrate Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Magaldrate Suspension:


Use Magaldrate Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Magaldrate Suspension may be taken with or without food.

  • Shake well before using.

  • If you miss a dose of Magaldrate Suspension and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Magaldrate Suspension.



Important safety information:


  • Do not exceed the recommended dose or use the maximum dose for more than 2 weeks without checking with your doctor.

  • Magaldrate Suspension contains aluminum and magnesium. Before you begin taking any new prescription or over-the-counter medicine, read the ingredients to see if it also contains aluminum or magnesium. If it does or if you are uncertain, contact your doctor or pharmacist.

  • PREGNANCY and BREAST-FEEDING: It is unknown if Magaldrate Suspension can cause harm to the fetus. If you become pregnant while taking Magaldrate Suspension, discuss with your doctor the benefits and risks of using Magaldrate Suspension during pregnancy. Magaldrate Suspension is excreted in breast milk. If you are or will be breast-feeding while you are using Magaldrate Suspension, check with your doctor or pharmacist to discuss the risks to your baby.


Possible side effects of Magaldrate Suspension:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; intestinal pain.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; loss of appetite; muscle weakness; nausea; slow reflexes; vomiting; vomit that looks like coffee grounds.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Magaldrate side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Magaldrate Suspension:

Store Magaldrate Suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Magaldrate Suspension out of the reach of children and away from pets.


General information:


  • If you have any questions about Magaldrate Suspension, please talk with your doctor, pharmacist, or other health care provider.

  • Magaldrate Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Magaldrate Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Magaldrate resources


  • Magaldrate Side Effects (in more detail)
  • Magaldrate Use in Pregnancy & Breastfeeding
  • Magaldrate Drug Interactions
  • Magaldrate Support Group
  • 0 Reviews for Magaldrate - Add your own review/rating


Compare Magaldrate with other medications


  • Indigestion

Isopropylantipyrine




Isopropylantipyrine may be available in the countries listed below.


Ingredient matches for Isopropylantipyrine



Propyphenazone

Isopropylantipyrine (JAN) is known as Propyphenazone in the US.

International Drug Name Search

Glossary

JANJapanese Accepted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Friday, 22 June 2012

Indobene retard




Indobene retard may be available in the countries listed below.


Ingredient matches for Indobene retard



Indometacin

Indometacin is reported as an ingredient of Indobene retard in the following countries:


  • Austria

International Drug Name Search

Thursday, 21 June 2012

Tasmar 100 mg Tablets






Tasmar 100 mg film-coated tablets



Tolcapone




Read all of this leaflet carefully before you start taking this medicine.


  • Keep this leaflet. You may need to read it again.

  • If you have further questions, please ask your doctor or your pharmacist.

  • This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

  • If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.




In this leaflet:


  • 1. What Tasmar is and what it is used for

  • 2. Before you take Tasmar

  • 3. How to take Tasmar

  • 4. Possible side effects

  • 5. How to store Tasmar

  • 6. Further information




What Tasmar Is And What It Is Used For


Tasmar is used together with levodopa/benserazide or levodopa/carbidopa when all other alternative medicines cannot stabilise your Parkinson’s disease.


Catechol-O-methyltransferase (COMT) is a natural enzyme in your body that breaks down the levodopa medication used to treat your Parkinson’s disease. Tasmar blocks COMT and slows the breakdown of levodopa. This means when it is taken together with levodopa (as levodopa/benserazide or levodopa/carbidopa) you should have an improvement in your symptoms of Parkinson’s disease.




Before You Take Tasmar



Do not take Tasmar:


  • if you have liver disease or increased liver enzymes

  • if you have severe dyskinesia (involuntary movement)

  • if you have a previous history of Neuroleptic Malignant Syndrome (NMS) Symptom Complex (severe symptoms of muscle stiffening, fever or mental confusion) and / or if you have non-traumatic Rhabdomyolysis (damage of skeletal muscle tissue) or Hyperthermia (fever).

  • if you are hypersensitive (allergic) to tolcapone or to any of the other ingredients of Tasmar.

  • if you have Phaeochromocytoma (a special type of tumor)

  • if you take non-selective mono amino oxidase (MAO) inhibitors (used to treat depression and anxiety)



Take special care with Tasmar:


  • you should not start taking Tasmar until your doctor has described the risks of treatment with Tasmar and measures necessary to minimise those risks, and answered any questions you may have. You should only receive Tasmar if your Parkinson’s disease is not adequately controlled by the use of other therapies. In addition, your doctor will stop Tasmar treatment if after 3 weeks you do not improve enough to justify the risks of continuing treatment.

  • Liver Injury:

    Tasmar may cause rare but potentially fatal liver injury. Liver injury has occurred most often after 1 month and before 6 months. Injury occurring earlier or later is also possible.

    It should also be noted that female patients may have a higher risk of liver injury.

    Before beginning treatment: To reduce the risk of liver injury you should not use Tasmar if 1) you have liver disease or 2) blood tests done before starting treatment show any liver abnormality (tests of ALT, alanine amino transferase and AST, aspartate amino transferase).

    While receiving treatment: Blood tests will be done every 2 weeks for the first year of therapy, every 4 weeks for the next 6 months and every 8 weeks thereafter and treatment will be stopped if they become abnormal.

  • the treatment with Tasmar may sometimes lead to disturbances in the way the liver works. Therefore, if you experience symptoms such as nausea, vomiting, pain in your stomach (particulary over the liver in the right upper area), loss of appetite, weakness, fever, darkening of urine, jaundice (yellow of the skin or eyes) or if you tire more easily, you should contact your doctor immediately.

  • if you have taken already Tasmar and developed acute liver injury while on Tasmar, it should not be re-introduced again.

  • NMS (Neuroleptic Malignant Syndrome):

    Symptoms of Neuroleptic Malignant Syndrome may occur during Tasmar treatment. NMS (Neuroleptic Malignant Syndrome) consists of some or all of the following: severe muscle stiffness, jerking movements of muscles, arms or legs, and soreness of muscles. Muscle injury can sometimes cause dark urine. Other important symptoms are high fever and mental confusion. Very rarely, after abruptly reducing or stopping Tasmar or other antiparkinsonian drugs, you may experience severe symptoms of muscle stiffening, fever or mental confusion. If this happens notify your doctor.

    Before beginning treatment: To reduce the risk of NMS you should not use Tasmar if your doctor says you have severe dyskinesia (involuntary movement) or a previous illness that may have been NMS. Inform your doctor of all prescription and non-prescription medications as the risk of NMS may be increased if you are taking medications that may alter the effects of the brain messenger molecules of dopamine and serotonin.

    While receiving treatment: If you develop symptoms as described above, that you think may be NMS, you should report them to your doctor immediately. Do not stop Tasmar or any other Parkinson’s medications without telling your doctor as this may increase the risk of NMS.

  • if you have any illnesses other than Parkinson’s disease.

  • if you are allergic to other medicines, foods and dyes.

  • soon after beginning and during your treatment with Tasmar, you may have symptoms caused by levodopa such as dyskinesia (involuntary movement) and nausea. If you feel unwell, you should contact your doctor because you may need to take less levodopa.



Taking other medicines


Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed (non-prescription medicines and herbals).


Please inform your doctor about all other medicines you are taking especially anti-depressants, alpha-methyldopa (used to treat increases blood pressure), apomorphine (used for Parkinson’s disease), dobutamine (used for the chronic heart disease), adrenaline and isoprenaline (both used for heart attacks).


When you are taking Tasmar with anticoagulants (that prevent blood clotting) of the warfarin type, your doctor may perform regular blood tests to monitor how easily the blood clots.


If you go to hospital or if you are prescribed a new medicine, you must tell your doctor that you are taking Tasmar.




Taking Tasmar with food and drink


Tasmar can be taken with or without food.




Pregnancy and breast-feeding


You must tell your doctor if you are pregnant or intend to become pregnant. Your doctor will discuss the risks and benefits of taking Tasmar during pregnancy.


The effects of Tasmar have not been studied in infants. You should not breast-feed your infant during treatment with Tasmar.




Driving and using machines


Tasmar has an effect on your symptoms of Parkinson’s disease. Since your ability to drive a car or operate machinery may be affected by Parkinson’s disease, you should discuss this with your doctor.


Tasmar used with your other Parkinson medicines can cause somnolence (excessive drowsiness) and sudden sleep onset episodes (you may suddenly fall asleep). Therefore you must refrain from driving or engaging in activities where impaired alertness may put yourself or others at risk of serious injury or death (e.g. operating machines) until such recurrent episodes and somnolence have resolved.




Important information about some of the ingrediensts of Tasmar


If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.





How To Take Tasmar


Always take Tasmar exactly as your doctor has told you. You should check with your doctor if you are unsure. Do not break or crush tablets. Swallow Tasmar with water.



Dose and frequency of administration


When beginning and during treatment with Tasmar, your dose of levodopa may need to be changed. Your doctor will advise you what to do.


Your doctor should always begin your treatment with the standard dose (100 mg (1 tablet) three times a day). If benefits are not seen within 3 weeks of the initiation of the treatment, Tasmar should be discontinued. The dose should only be increased to the higher dose (200 mg three times a day) if the increase in how your Parkinson’s disease symptoms are controlled outweighs the expected increase in side effects. The side effects at the higher dose can often be severe and affect your liver. If you do not get better at the higher dose after a total of 3 weeks, your doctor should stop your treatment with Tasmar.


The first dose of Tasmar is taken with the first dose of the day of levodopa and the other doses of Tasmar are taken about 6 and 12 hours later. Take one tablet in the morning, one tablet in the middle of the day and one tablet in the evening.



If you take more Tasmar than you should


Contact a doctor, pharmacist or hospital immediately as you may need urgent medical attention.


If another person accidentally takes your medicine, contact a doctor or hospital immediately as he or she may need urgent medical attention.


Symptoms of overdose may include nausea, vomiting, dizziness and breathing difficulties.




If you forget to take Tasmar


Take it as soon as you remember, then continue to take it at the usual times. If you have missed several doses, please inform your doctor and follow the advice given to you.


Do not take a double dose to make up for forgotten individual doses.




If you stop taking Tasmar


Do not reduce or stop taking your medicine unless your doctor tells you to. Always follow the instructions of your doctor about the duration of the treatment with Tasmar.





Possible Side Effects


Like all medicines, Tasmar can have side effects, although not everybody gets them. Tell your doctor or a pharmacist as soon as possible if you do not feel well while you are taking Tasmar



Disturbances in the way the liver works, sometimes severe hepatitis, have been observed. Therefore, if you experience symptoms such as nausea, vomiting, abdominal pain, loss of appetite, weakness, fever, darkening of urine or jaundice you should contact your doctor immediately.


The frequency of possible side effects listed below is defined using the following convention:


Very common (affects more than 1 user in 10)


Common (affects 1 to 10 users in 100)


Uncommon (affects 1 to 10 users in 1,000)


Rare (affects 1 to 10 users in 10,000)


Very rare (affects less than 1 user in 10,000)


Not known (frequency cannot be estimated from the available data).


Side effects that may occur very commonly are: dyskinesia (involuntary movement), nausea, sleeping problems, decreased appetite, diarrhoea, fainting, feeling lightheaded when you stand, hallucination, headache, confusion and sleepiness.


Commonly, chest pain, constipation, vomiting, stomach ache, dry mouth and increased sweating may occur during treatment with Tasmar. Further common side effects that may occur are, dystonia, influenza and influenza like symptoms


Very rarely, patients develop Neuroleptic Malignant Syndrome (severe symptoms of muscle stiffening, fever or mental confusion) when antiparkinsonian treatments are abruptly reduced or withdrawn.


Soon after beginning and during your treatment with Tasmar, you may have symptoms caused by levodopa such as involuntary movement and nausea. Therefore, if you feel unwell, you should contact your doctor since you may need to have your levodopa dose changed.


Contact your doctor if you develop persistent or severe diarrhoea.


This medicine can cause a harmless yellow urine discoloration. However if you notice a darkening of your urine this could be a sign of muscle injury or liver injury, please inform your doctor.


If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.




How To Store Tasmar


Keep out of the reach and sight of children.


Do not use after the expiry date stated on the pack.


This medicinal product does not require any special storage conditions


Do not use Tasmar if you notice that the tablets are damaged.




Further Information



What Tasmar contains


  • The active substance is tolcapone (100 mg in each film- coated tablet)

  • The other ingredients are:

    Tablet core: Calcium hydrogen phosphate, Microcrystalline cellulose, Povidone K30, Sodium starch glycollate, Lactose, Talc, Magnesium stearate.

    Film-coat: Hydroxypropylmethylcellulose, Talc, Yellow iron oxide, Ethylcellulose, Titanium dioxide, Triacetin, Sodium lauril sulfate.



What Tasmar looks like and contents of the pack


Tasmar is a pale to light yellow, oval shaped, film-coated tablet. “TASMAR” and “100” are engraved on one side. Tasmar is supplied as film-coated tablets containing 100 mg tolcapone. It is available in blisters in pack sizes of 30 and 60 tablets and in glass bottles in pack sizes of 30, 60 and 100 tablets.


Not all pack-sizes may be marketed.




Marketing Authorisation Holder and Manufacturer



The marketing authorisation holder is:



Meda AB

Pipers väg 2A

S-170 09 Solna

Sweden



The manufacturer responsible for batch release is:



ICN Polfa Rzeszów S.A.

ul. Przemysłowa 2

35-959 Rzeszów

Poland



For any information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder.
































United Kingdom

Meda Pharmaceuticals Ltd.

Skyway House

Parsonage Road

Takeley

Bishop’s Stortford

CM22 6PU

UK

Tel:+44 845 460 0000




This leaflet was last approved in: October 2009


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Tussall-ER


Generic Name: dexbrompheniramine, dextromethorphan, and phenylephrine (dex brom feh NEER a meen, dex tro meh THOR fan, and feh nill EFF rin)

Brand Names: Dexall, Tussall, Tussall-ER, Y-Cof DM


What is Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?

Dexbrompheniramine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of dexbrompheniramine, dextromethorphan, and phenylephrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.


This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Dexbrompheniramine, dextromethorphan, and phenylephrine may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?


Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What should I discuss with my healthcare provider before taking Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?


Do not use cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:



  • a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;




  • diabetes;




  • liver or kidney disease;




  • epilepsy or other seizure disorder;




  • cough with mucus, or cough caused by emphysema or chronic bronchitis;




  • enlarged prostate or urination problems;




  • low blood pressure;




  • pheochromocytoma (an adrenal gland tumor); or




  • if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).




FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Do not use cough or cold medicine without medical advice if you are pregnant. This medicine may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use cough or cold medicine without medical advice if you are breast-feeding a baby.

How should I take Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?


Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.


Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.


Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.


Do not crush, chew, break, or open an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?


Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.


What should I avoid while taking Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?


This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of this medication. Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Antihistamines, cough suppressants, and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.


Avoid becoming overheated or dehydrated during exercise and in hot weather. This medication can decrease sweating and you may be more prone to heat stroke.

Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heart rate;




  • severe headache, mood changes, hallucinations;




  • severe dizziness or anxiety, feeling like you might pass out;




  • tremor, seizure (convulsions);




  • easy bruising or bleeding, unusual weakness;




  • fever;




  • urinating less than usual or not at all;




  • feeling short of breath; or




  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).



Less serious side effects may include:



  • mild headache;




  • mild dizziness, drowsiness;




  • dry mouth, nose, or throat;




  • nausea, diarrhea, constipation, upset stomach;




  • feeling nervous, restless, or irritable;




  • blurred vision; or




  • sleep problems (insomnia).



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Tussall-ER (dexbrompheniramine, dextromethorphan, and phenylephrine)?


Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by dexbrompheniramine or dextromethorphan.


Ask a doctor or pharmacist if it is safe for you to take this medication if you are also using any of the following drugs:



  • atropine (Atreza, Sal-Tropine);




  • benztropine (Cogentin);




  • topiramate (Topamax);




  • zonisamide (Zonegran);




  • an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil, Pexeva), sertraline (Zoloft), venlafaxine (Effexor), and others;




  • anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);




  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;




  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);




  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or




  • ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).



This list is not complete and other drugs may interact with dexbrompheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Tussall-ER resources


  • Tussall-ER Side Effects (in more detail)
  • Tussall-ER Use in Pregnancy & Breastfeeding
  • Tussall-ER Drug Interactions
  • Tussall-ER Support Group
  • 0 Reviews for Tussall-ER - Add your own review/rating


  • Y-Cof DM Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Tussall-ER with other medications


  • Cough and Nasal Congestion


Where can I get more information?


  • Your pharmacist can provide more information about dexbrompheniramine, dextromethorphan, and phenylephrine.

See also: Tussall-ER side effects (in more detail)


Tuesday, 19 June 2012

Loestrin 1/20


Pronunciation: nor-eth-IN-drone/ETH-in-il ess-tra-DYE-ole
Generic Name: Norethindrone/Ethinyl Estradiol
Brand Name: Examples include Loestrin 1/20 and Ovcon 35

Cigarette smoking increases the risk of serious heart and blood vessel side effects from birth control pill use. This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite significant in women older than 35 years of age. Women who use birth control pills are strongly advised not to smoke.





Loestrin 1/20 is used for:

Prevention of pregnancy. It may also be used to regulate the menstrual cycle. It does NOT protect against HIV infection (AIDS) and other sexually transmitted diseases. It may also be used for other conditions as determined by your doctor.


Loestrin 1/20 is a combination of 2 female sex hormones, estrogen and progestin. Loestrin 1/20 works by preventing the ovaries from releasing eggs. When there is no egg to be fertilized, pregnancy cannot occur. It also thickens the cervical mucus, making it difficult for sperm to enter the uterus.


Do NOT use Loestrin 1/20 if:


  • you are allergic to any ingredient in Loestrin 1/20

  • you are pregnant or think you may be pregnant

  • you have or have ever had abnormal growth or cancer of the breast, cervical or uterine cancer, or unexplained vaginal bleeding

  • you have or have ever had stoppage or rupture of blood vessels in the brain (stroke); blockage of blood vessels (blood clots) in the legs, lungs, heart (heart attack or angina/chest pain), or other parts of the body; heart valve problems; or severe high blood pressure

  • you have liver disease, liver tumors, or yellowing of the eyes or skin during pregnancy or during previous use of Loestrin 1/20 or a similar medicine

  • you are taking acitretin, aprepitant, barbiturates (eg, phenobarbital), bosentan, carbamazepine, felbamate, griseofulvin, hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), protease inhibitors (eg, indinavir), rifamycins (eg, rifampin), St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone

Contact your doctor or health care provider right away if any of these apply to you.



Before using Loestrin 1/20:


Some medical conditions may interact with Loestrin 1/20. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines or other substances

  • if you smoke cigarettes or are 35 years of age or older

  • if you have breast nodules, disease of the breast, an abnormal breast x-ray or mammogram, or a strong family history of breast cancer

  • if you have vision problems, depression, diabetes, epilepsy (seizures), gallbladder or liver disease, heart problems, high blood pressure, kidney disease, or migraine headaches

  • if you have high cholesterol, triglycerides, or calcium in the blood; pancreas disease; obesity; or uterine fibroids or endometriosis

  • if you are going to have surgery or you will be on bed rest

Some MEDICINES MAY INTERACT with Loestrin 1/20. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Acitretin, aprepitant, azole antifungals (eg, ketoconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, felbamate, griseofulvin, hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), protease inhibitors (eg, indinavir), rifamycins (eg, rifampin), St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone because they may decrease Loestrin 1/20's effectiveness. While on these medicines, you will need an alternative form of birth control (eg, condoms) until your next period after stopping these medicines.

  • Beta-blockers (eg, metoprolol), cyclosporine, theophyllines, or troleandomycin because the risk of their side effects or toxicity may be increased by Loestrin 1/20

  • Corticosteroids (eg, prednisone) because their side effects, including rounding of the face, weight gain, fluid retention, elevated blood pressure, elevated blood sugar, or skin changes, may be increased by Loestrin 1/20

  • Oral anticoagulants (eg, warfarin) because their side effects, including risk of bleeding, may be increased by Loestrin 1/20; however, it is also possible that the effectiveness may also be decreased by Loestrin 1/20

  • Lamotrigine because its effectiveness may be decreased by Loestrin 1/20; stopping Loestrin 1/20 may lead to severe side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Loestrin 1/20 may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Loestrin 1/20:


Use Loestrin 1/20 as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • An extra patient leaflet is available with Loestrin 1/20. Talk to your pharmacist if you have questions about this information.

  • Take Loestrin 1/20 by mouth with food.

  • If you have trouble remembering to take Loestrin 1/20, talk to your doctor about how to make pill-taking easier or about using another method of birth control.

  • Always have another kind of birth control (eg, condoms) to use as a backup in case you miss pills. Also, always keep an extra, full pack of pills.

  • Decide what time of day you want to take your medicine. It is important that you take it at about the same time every day.

  • Do not skip pills even if you are spotting or bleeding between monthly periods or feel sick to your stomach (nausea).

  • Do not skip pills even if you do not have sex very often.

  • If you miss a dose of Loestrin 1/20, take it as soon as your remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. If you miss more than 1 dose of Loestrin 1/20, refer to the patient information that came with Loestrin 1/20 or contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Loestrin 1/20.



Important safety information:


  • Loestrin 1/20 may increase the risk of stroke, heart attack, blood clots, high blood pressure, or similar problems. The risk may be greater if you smoke.

  • There may be times when you may not have regular menstrual periods after you have taken a pack of Loestrin 1/20 for a cycle. If you have taken Loestrin 1/20 regularly and missed 1 period, keep taking Loestrin 1/20 for the next cycle but be sure to tell your doctor first.

  • If you have not taken Loestrin 1/20 daily as instructed and missed a period, or if you missed 2 consecutive periods, you may be pregnant. You could get pregnant if you have sex in the 7 days after you miss pills. Do not continue to take Loestrin 1/20 until you are sure that you are not pregnant, but continue to use another method of birth control (eg, condoms).

  • Contact your doctor if you miss any menstrual periods so that the cause may be determined.

  • Follow your doctor's instructions to examine your breasts, and report any lumps to your doctor immediately.

  • Tell your doctor or dentist that you take Loestrin 1/20 before you receive any medical or dental care, emergency care, or surgery.

  • If you will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor 3 to 4 weeks in advance. Special precautions may be needed.

  • Loestrin 1/20 does not stop the spread of HIV or sexually transmitted diseases (STDs) to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have an HIV infection or an STD. Do not share needles, injection supplies, or items like toothbrushes or razors.

  • Taking certain antibiotics or anticonvulsants while you are using Loestrin 1/20 may decrease the effectiveness of Loestrin 1/20. To prevent pregnancy, use an additional form of birth control (eg, condoms) until your next menstrual period.

  • If you wear contact lenses and you develop problems with them, contact your doctor.

  • Loestrin 1/20 may cause dark skin patches on your face. Avoid the sun, sunlamps, or tanning booths until you know how you react to Loestrin 1/20. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Diabetes patients - Loestrin 1/20 may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

  • Loestrin 1/20 may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Loestrin 1/20.

  • Lab tests, including PAP tests, may be performed while you use Loestrin 1/20. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Loestrin 1/20 should not be used in CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed.

  • PREGNANCY and BREAST-FEEDING: Do not use Loestrin 1/20 if you are pregnant. If you think you may be pregnant, contact your doctor right away. Loestrin 1/20 is found in breast milk. Do not breast-feed while taking Loestrin 1/20.


Possible side effects of Loestrin 1/20:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Breast tenderness; bleeding between menstrual periods; change in vaginal mucus; headache; loss of scalp hair; nausea; nervousness; rash; spotty darkening of the skin (especially on the face); stomach cramps and bloating; vaginal infection; vomiting; weight or appetite change.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast lumps; calf or leg pain or swelling; chest pain; coughing of blood; dark urine or light-colored bowel movements; depression; dizziness or fainting; fever; heaviness in the chest; lack of energy or fatigue; loss of appetite; mood change; numbness in arm or leg; partial or complete loss of vision or other vision changes; sleeping problems; slurred speech; stomach pain or tenderness; sudden severe headache; sudden shortness of breath; swelling of the fingers or ankles; weakness on one side of the body; yellowing of the skin or eyes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Loestrin/20 side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea; vaginal bleeding.


Proper storage of Loestrin 1/20:

Store Loestrin 1/20 at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store Loestrin 1/20 in the container it came in, tightly closed, away from heat, moisture, and light. Do not store in the bathroom. Keep Loestrin 1/20 out of the reach of children and away from pets.


General information:


  • If you have any questions about Loestrin 1/20, please talk with your doctor, pharmacist, or other health care provider.

  • Loestrin 1/20 is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Loestrin 1/20. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Loestrin 1/20 resources


  • Loestrin 1/20 Side Effects (in more detail)
  • Loestrin 1/20 Use in Pregnancy & Breastfeeding
  • Loestrin 1/20 Drug Interactions
  • Loestrin 1/20 Support Group
  • 7 Reviews for Loestrin/20 - Add your own review/rating


Compare Loestrin 1/20 with other medications


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  • Prevention of Osteoporosis