Tolvaptan

In the US, Tolvaptan (tolvaptan systemic) is a member of the drug class vasopressin antagonists and is used to treat Euvolemic Hyponatremia and Hyponatremia.

US matches:

• Tolvaptan

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

C03XA01

CAS registry number (Chemical Abstracts Service)

0150683-30-0

Chemical Formula

C26-H25-Cl-N2-O3

Molecular Weight

448

Therapeutic Categories

Diuretic agent

Treatment of heart failure

Treatment of hyponatremia

Vasopressin V2 receptor antagonist

Chemical Names

(+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide (WHO)

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl- (USAN)

N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide (IUPAC)

N-{4-[(6R)-9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl]-3-methyl-phenyl}-2-methyl-benzamide

Foreign Names

• Tolvaptanum (Latin)
• Tolvaptan (German)
• Tolvaptan (French)
• Tolvaptán (Spanish)

Generic Names

• Tolvaptan (OS: USAN, JAN)
• OPC-41061 (IS)
• UNII-21G72T1950 (IS)

Brand Names

• Samsca
  Otsuka, Germany; Otsuka, Sweden; Otsuka, United States; Otsuka Pharmaceuticals, United Kingdom

International Drug Name Search

Glossary

IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.